Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer's Disease Neuroimaging Initiative.

Autor:	Thomas KR; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Eppig JS; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA., Weigand AJ; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA., Edmonds EC; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Wong CG; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Jak AJ; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Delano-Wood L; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Galasko DR; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Salmon DP; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Edland SD; Department of Biostatistics, University of California, San Diego, La Jolla, CA, USA; Department of Family and Preventative Medicine, University of California, San Diego, La Jolla, CA, USA., Bondi MW; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA. Electronic address: mbondi@ucsd.edu.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2019 Apr; Vol. 15 (4), pp. 561-569. Date of Electronic Publication: 2019 Jan 11.
DOI:	10.1016/j.jalz.2018.10.008
Abstrakt:	Introduction: We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Methods: CN and MCI participants were identified as remaining stable, progressing, or reverting at 1-year of follow-up (Year 1). Application of ADNI's MCI criteria at Year 1 in addition to Alzheimer's disease biomarkers by group were examined. Results: The MCI-to-CN reversion rate was 3.0%. When specific components were examined, 22.5% of stable MCI participants had normal memory performance at Year 1 and their Alzheimer's disease biomarkers were consistent with the stable CN group. At Year 1, when all MCI criteria were not met, the more subjective Clinical Dementia Rating rather than objective memory measure appeared to drive continuation of the MCI diagnosis. Discussion: Results demonstrate an artificially low 1-year MCI-to-CN reversion rate in ADNI-diagnosed participants. If the Logical Memory cutoffs had been consistently applied, the reversion rate would have been at least 21.8%. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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