Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide.

Autor: Navya PN; Nano-Bio interfacial research laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur 572103, Karnataka, India. Electronic address: navyapn@sit.ac.in., Madhyastha H; Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 8891692, Miyazaki, Japan., Madhyastha R; Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 8891692, Miyazaki, Japan., Nakajima Y; Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 8891692, Miyazaki, Japan., Maruyama M; Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 8891692, Miyazaki, Japan., Srinivas SP; School of Optometry, Indiana University, Bloomington, IN 47405, USA., Jain D; Department of Molecular Biology and Biotechnology, Rajasthan College of Agriculture, Maharana Pratap University of Agriculture and Technology, Udaipur 313001, Rajasthan, India., Amin MH; Centre for Advanced Materials and Industrial Chemistry, School of Science, RMIT University, Melbourne, VIC 3001, Australia., Bhargava SK; Centre for Advanced Materials and Industrial Chemistry, School of Science, RMIT University, Melbourne, VIC 3001, Australia., Daima HK; Nano-Bio interfacial research laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur 572103, Karnataka, India; Centre for Advanced Materials and Industrial Chemistry, School of Science, RMIT University, Melbourne, VIC 3001, Australia; Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi highway, Jaipur 303002, Rajasthan, India. Electronic address: hkdaima@jpr.amity.edu.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Mar; Vol. 96, pp. 286-294. Date of Electronic Publication: 2018 Nov 22.
DOI: 10.1016/j.msec.2018.11.024
Abstrakt: Manufacturing nanoparticles with controlled physicochemical properties using environment-friendly routes have potential to open new prospects for a variety of applications. Accordingly, several approaches have been established for manufacturing metal nanoparticles. Many of these approaches entail the use of hazardous chemicals and could be toxic to the environment, and cannot be used readily for biomedical applications. In the present work, we report a single step bio-friendly approach to formulate gold (Au), silver (Ag), and Au-Ag alloy nanoparticles with desired surface corona and composition using isonicotinylhydrazide (INH) as a reducing agent. INH also functioned as a stabilizing agent by enabling a surface corona around the nanoparticles. Remarkably, within a single step INH could also provide a handle in regulating the composition of Au and Ag in bimetallic systems without any additional chemical modification. The physicochemical and surface properties of the different nanoparticles thus obtained have been examined by analytical, spectroscopic and microscopic techniques. Cell cytotoxicity (release of lactate dehydrogenase), cell viability and intracellular reactive oxygen species (ROS) assays confirmed that the Au, Ag, and Au-Ag bimetallic nanoparticles prepared with INH are biocompatible. Finally, the presence of organic surface corona of INH on the nanoparticles was found to impart nanozyme activity and antimycobacterial sensitivity to the nanoparticles.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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