Initial antimicrobial treatment of foals with sepsis: Do our choices make a difference?

Autor: Theelen MJP; Utrecht University, Faculty of Veterinary Medicine, Department of Equine Sciences, Yalelaan 112, 3584 CM, Utrecht, The Netherlands; Utrecht University, Faculty of Veterinary Medicine, Department of Infectious Diseases & Immunology, Yalelaan 1, 3584 CL, Utrecht, The Netherlands. Electronic address: m.j.p.theelen@uu.nl., Wilson WD; University of California, School of Veterinary Medicine, Department of Medicine & Epidemiology, 1 Shields Ave, Davis, CA, 95616, USA., Byrne BA; University of California, School of Veterinary Medicine, Department of Pathology, Microbiology & Immunology, 1 Shields Ave, Davis, CA, 95616, USA., Edman JM; University of California, School of Veterinary Medicine, Department of Medicine & Epidemiology, 1 Shields Ave, Davis, CA, 95616, USA., Kass PH; University of California, School of Veterinary Medicine, Department of Population Health and Reproduction, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA., Magdesian KG; University of California, School of Veterinary Medicine, Department of Medicine & Epidemiology, 1 Shields Ave, Davis, CA, 95616, USA.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2019 Jan; Vol. 243, pp. 74-76. Date of Electronic Publication: 2018 Nov 27.
DOI: 10.1016/j.tvjl.2018.11.012
Abstrakt: The study objectives were to provide cumulative antimicrobial susceptibility data at the patient level and to evaluate the effect of initial antimicrobial treatment on survival in foals with sepsis. Foals below 30days of age with a diagnosis of sepsis, confirmed by isolation of bacteria from normally sterile sites on the day of hospital admission, were included. Susceptibility testing was performed using the broth microdilution procedure. In total, 213 foals and 306 bacterial isolates were included. The likelihood of survival for foals from which all bacteria were susceptible to the initial antimicrobial treatment was 65.4% (n=106/162; 95% confidence interval (CI) 57.6% to 72.7%) versus 41.7% (n=10/24; 95% CI 22.1% to 63.4%) if one or more isolates were resistant (relative risk 1.57, 95% CI 0.96 to 3.06). Based on this study, amikacin combined with ampicillin remains an appropriate antimicrobial drug combination for initial treatment of foals with sepsis.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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