Derivation of iPSC lines from two patients with familial Alzheimer's disease from India.

Autor:	Najar AH; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bengaluru, India; Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India., Sneha KM; Institute for Stem Cell Biology and Regenerative Medicine (InStem), Bengaluru, India., Ashok A; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Babu S; Institute for Stem Cell Biology and Regenerative Medicine (InStem), Bengaluru, India., Subramaniam AG; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Kannan R; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Viswanath B; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Purushottam M; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Varghese M; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Parvez S; Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India., Panicker MM; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bengaluru, India; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, USA., Mukherjee O; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bengaluru, India; Institute for Stem Cell Biology and Regenerative Medicine (InStem), Bengaluru, India. Electronic address: omukherjee@ncbs.res.in., Jain S; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bengaluru, India; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Electronic address: sjain.nimhans@nic.in.
Jazyk:	angličtina
Zdroj:	Stem cell research [Stem Cell Res] 2019 Jan; Vol. 34, pp. 101370. Date of Electronic Publication: 2018 Dec 19.
DOI:	10.1016/j.scr.2018.101370
Abstrakt:	The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD. (Copyright © 2018. Published by Elsevier B.V.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu