Circulating microRNA profile in a mouse model of Crimean-Congo haemorrhagic fever.

Autor: Ferraris O; French Armed Forces Biomedical Research Institute (IRBA), 91220, Brétigny sur Orge, France., Moroso M; Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, 69007, Lyon, France., Siracusa J; French Armed Forces Biomedical Research Institute (IRBA), 91220, Brétigny sur Orge, France., Jarjaval F; French Armed Forces Biomedical Research Institute (IRBA), 91220, Brétigny sur Orge, France., Goriot ME; French Armed Forces Biomedical Research Institute (IRBA), 91220, Brétigny sur Orge, France; UMR-MD-1197, INSERM, Université Paris Sud, Clamart, France., Peyrefitte CN; French Armed Forces Biomedical Research Institute (IRBA), 91220, Brétigny sur Orge, France. Electronic address: cpeyrefitte2000@yahoo.fr., Banzet S; French Armed Forces Biomedical Research Institute (IRBA), 91220, Brétigny sur Orge, France; UMR-MD-1197, INSERM, Université Paris Sud, Clamart, France.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2019 Apr 02; Vol. 263, pp. 16-20. Date of Electronic Publication: 2018 Dec 31.
DOI: 10.1016/j.virusres.2018.12.018
Abstrakt: Crimean-Congo haemorrhagic fever (CCHF) is a severe disease leading to high mortality in humans. Early diagnosis and evaluation of the severity are necessary to improve patient survival. In a model of CCHF virus-infected interferon-receptor-deficient (IFNAR) KO mice, we found a specific circulating miRNA (c-miRNA) profile when compared to wild-type (wt), resistant mice. Among this response, 20 c-miRNA were shown to be specifically altered, including miR-122-5p, miR-216a-5p, 217-5p, miR-29a-3p and miR-511-5p. Using a logistic regression analysis, a combination of 8 miRNAs allowed a 100% discrimination of mice developing a severe illness (IFNAR-KO) from non-detectable clinical signs (wt).
(Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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