It's all about tau.

Autor: Tapia-Rojas C; Laboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile., Cabezas-Opazo F; Laboratory of Neurodegenerative Diseases, Centro de Investigación Biomédica, Universidad Autónoma de Chile, Santiago, Chile., Deaton CA; Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, NY, USA., Vergara EH; Laboratory of Neurodegenerative Diseases, Centro de Investigación Biomédica, Universidad Autónoma de Chile, Santiago, Chile., Johnson GVW; Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, NY, USA., Quintanilla RA; Laboratory of Neurodegenerative Diseases, Centro de Investigación Biomédica, Universidad Autónoma de Chile, Santiago, Chile; Centro de Investigación y Estudio del Consumo de Alcohol en Adolescentes (CIIA), Santiago, Chile. Electronic address: rodrigo.quintanilla@uautonoma.cl.
Jazyk: angličtina
Zdroj: Progress in neurobiology [Prog Neurobiol] 2019 Apr; Vol. 175, pp. 54-76. Date of Electronic Publication: 2018 Dec 31.
DOI: 10.1016/j.pneurobio.2018.12.005
Abstrakt: Tau is a protein that is highly enriched in neurons and was originally defined by its ability to bind and stabilize microtubules. However, it is now becoming evident that the functions of tau extend beyond its ability to modulate microtubule dynamics. Tau plays a role in mediating axonal transport, synaptic structure and function, and neuronal signaling pathways. Although tau plays important physiological roles in neurons, its involvement in neurodegenerative diseases, and most prominently in the pathogenesis of Alzheimer disease (AD), has directed the majority of tau studies. However, a thorough knowledge of the physiological functions of tau and its post-translational modifications under normal conditions are necessary to provide the foundation for understanding its role in pathological settings. In this review, we will focus on human tau, summarizing tau structure and organization, as well as its posttranslational modifications associated with physiological processes. We will highlight possible mechanisms involved in mediating the turnover of tau and finally discuss newly elucidated tau functions in a physiological context.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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