Primary cutaneous B-cell lymphoma: A single-center 5-year experience.

Autor: Jacob LA; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Asati V; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Lakshmaiah KC; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Govind BK; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Lokanatha D; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Babu SM; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Lokesh KN; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Rudresh AH; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Rajeev LK; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Mulchandani NJ; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Anand A; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Koppaka D; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India., Mysore SN; Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India.
Jazyk: angličtina
Zdroj: Indian journal of cancer [Indian J Cancer] 2018 Apr-Jun; Vol. 55 (2), pp. 134-137.
DOI: 10.4103/ijc.IJC_418_17
Abstrakt: Background: Skin is the second most common site for extranodal non-Hodgkin's lymphoma (NHL). Most primary cutaneous NHLs are of T-cell origin (70%). Primary cutaneous B-cell lymphoma (PCBCL) is a rare entity.
Materials and Methods: Patients diagnosed with PCBCL between January 2012 and July 2017 at our center were retrospectively analyzed.
Results: Eight patients of PCBCL were diagnosed. Three patients (37.5%) were males while 5 patients (62.5%) were females. The median age at diagnosis was 45 years (range, 18-60 years). Scalp was the most common site of involvement (50% of the patients). Diffuse large B-cell lymphoma (DLBCL) was the most common histology (63%), with leg-type DLBCL diagnosed in 1 patient. Two patients had primary cutaneous follicle center lymphoma, whereas the remaining 1 patient had precursor B-lymphoblastic lymphoma. All 5 DLBCL cases were treated with CHOP chemotherapy, and rituximab was given to 3 patients. Of the primary cutaneous follicle center lymphomas, 1 patient with stage II disease was treated with CHOP and is alive without recurrence for the past 5 years, whereas the other patient is on observation alone. The patient with precursor B-lymphoblastic lymphoma was started on MCP-841 protocol; however, the patient did not complete the treatment and died after 11 months.
Conclusions: PCBCL is a heterogeneous group of diseases and dividing them into subtypes, based on morphology and immunophenotype, has therapeutic implications.
Competing Interests: None
Databáze: MEDLINE
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