Gender and Smoking Correlations of Surfactant Lipids and Proteins in the Saliva of Dental Patients.

Autor:	Adibi SS; Department of General Practice & Dental Public Health, University of Texas School of Dentistry at Houston, Houston, Texas 77054, USA., Alcorn JL; The McGovern Medical School at UTHealth, 6431 Fannin, Suite 3.222, Houston, Texas 77030, USA., Ono K; The McGovern Medical School at UTHealth, 6431 Fannin, Suite 3.222, Houston, Texas 77030, USA., Lichtenberger LM; The McGovern Medical School at UTHealth, 6431 Fannin, Suite 3.222, Houston, Texas 77030, USA.
Jazyk:	angličtina
Zdroj:	Journal of dental and maxillofacial surgery [J Dent Maxillofac Surg] 2018; Vol. 1 (1), pp. 67-70. Date of Electronic Publication: 2018 Oct 22.
DOI:	10.18314/jdms.v1i1.1385
Abstrakt:	We sought to determine the effects of smoking on surfactant lipids and proteins in saliva. Levels of sphingomyelin (Sph) phosphatidylcholine (PC) and lyso-PC (LPC) were determined by thin layer chromatography. Levels of surfactant protein A (SP-A) were determined by western analysis using antibodies specific for SP-A. Significance of the results was determined by the student's t -test. The LPC/PC ratio had a tendency to be much higher in smokers compared to nonsmokers. LPC levels were significantly higher in females smokers compared to male smokers. Additionally, levels of SP-A were significantly reduced in females smokers compared to non-smokers. Smoking alters surfactant protein and LPC/PC ratios in saliva. There is a significant difference in the effects in females compared to males. Findings suggest smoking alters the composition of saliva that may reduce protection of the oral cavity, which may explain why women smokers are at greater risk of developing oral mucositis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu