Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.

Autor: Norman LJ; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: luken@umich.edu., Taylor SF; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan., Liu Y; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan., Radua J; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Mental Health Research Networking Center, Barcelona, Spain; Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Chye Y; Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia., De Wit SJ; Amsterdam Neuroscience, Amsterdam University Medical Centers, Department of Psychiatry, Amsterdam, The Netherlands; Department of Anatomy & Neurosciences, Vrije Universiteit, GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands., Huyser C; Bascule, Academic Centre for Children and Adolescent Psychiatry, Amsterdam, The Netherlands., Karahanoglu FI; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Luks T; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California., Manoach D; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts., Mathews C; Department of Psychiatry and Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, Florida., Rubia K; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Suo C; Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia., van den Heuvel OA; Amsterdam Neuroscience, Amsterdam University Medical Centers, Department of Psychiatry, Amsterdam, The Netherlands; OCD Team, Haukeland University Hospital, Bergen, Norway., Yücel M; Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia., Fitzgerald K; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2019 May 01; Vol. 85 (9), pp. 713-725. Date of Electronic Publication: 2018 Nov 29.
DOI: 10.1016/j.biopsych.2018.11.010
Abstrakt: Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies.
Methods: A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male).
Results: Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p = .03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p = .02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p < .001).
Conclusions: A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.
(Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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