Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow.

Autor: Fernandes FH; UNESP - São Paulo State University, Medical School, Department Pathology - Rubião Júnior, 18.618-687, Botucatu, São Paulo, Brazil. Electronic address: fernandesfh@gmail.com., Umbuzeiro GA; UNICAMP - University of Campinas, Technology School - Paschoal Marmo, 1888, Limeira, São Paulo, Brazil. Electronic address: giselau@ft.unicamp.br., Salvadori DMF; UNESP - São Paulo State University, Medical School, Department Pathology Rubião Júnior, 18.618-687, Botucatu, São Paulo, Brazil. Electronic address: dfavero@fmb.unesp.br.
Jazyk: angličtina
Zdroj: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2019 Jan; Vol. 837, pp. 48-51. Date of Electronic Publication: 2018 Oct 12.
DOI: 10.1016/j.mrgentox.2018.10.003
Abstrakt: Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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