The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia.

Autor: Yang J; Department of Medical Imaging, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang 050000, Hebei Province, China. Electronic address: ran0511@sina.com.
Jazyk: angličtina
Zdroj: Microvascular research [Microvasc Res] 2019 May; Vol. 123, pp. 62-67. Date of Electronic Publication: 2018 Dec 27.
DOI: 10.1016/j.mvr.2018.12.005
Abstrakt: Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbating disease due to inducing cell death, apoptosis and senescence by oxidative stress. During brain tissue repair, ROS are act as signaling molecules and may be benefical for regulating angiogenesis and preventing tissue injury. New blood vessel formation is essentially required for rescuing tissue from brain ischemia. In ischemic conditions, ROS promotes angiogenesis, either directly or via the generation of active oxidation products. ROS-induced angiogenesis involves several signaling pathways. This paper reviewed current understanding of the role of ROS as a mediator and modulator of angiogenesis in brain ischemia.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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