[Effects of quercetin on protective capacity in rats fed a high-fructose diet].

Autor:	Aksenov IV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Avren'eva LI; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Guseva GV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Trusov NV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Balakina AS; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Mzhel'skaya KV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Soto CJ; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Kravchenko LV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow., Tutelyan VA; Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.; I.M. Sechenov First Moscow State Medical University.
Jazyk:	ruština
Zdroj:	Voprosy pitaniia [Vopr Pitan] 2018; Vol. 87 (5), pp. 6-12. Date of Electronic Publication: 2018 Sep 13.
DOI:	10.24411/0042-8833-2018-10047
Abstrakt:	The purpose of the study was to determine effects of quercetin on protective capacity parameters in the experiment on rats fed a high fructose diet. Rats of the control group received a semi-synthetic (s/s) diet and water; animals from the 1st experimental group - s/s diet and 20% fructose solution instead of drinking water; rats of the 2nd experimental group- s/s diet with quercetin (0.1% indiet) and 20% fructose solution instead of drinking water for 20 weeks. Parameters of antioxidant status [total antioxidant activity (AOA), the content of malondialdehyde (MDA) and lipids hydroperoxides, the level of reduced and oxidized glutathione, activity of superoxide dismutase, catalase, glutathione peroxidase, paraoxonase-1, hemeoxygenase-1, NAD(P)H-quinone oxidoreductase], the activity of xenobiotic-metabolizing enzymes [CYP1A1, CYP1A2, CYP2B1, CYP3A, UDP-glucuronosyltransferase (UDP-GT) and glutathione transferase] were studied in plasma and liver of rats. Consumption of the high-fructose diet led to changes in some parameters: diminution of AOA in blood plasma, decrease of AOA and MDA level, unsedimentable activity of lysosomal enzymes, increase of the UDP-GT activity in liver. The inclusion of quercetin in the diet did not affect the studied parameters, except for a more pronounced decrease of the unsedimentable activity of lysosomal enzymes in rat liver. The results of the study indicated that there was no significant effect of quercetin on the protective capacity of rats at the initial stage of obesity caused by high-fructose diet. Competing Interests: The authors declare no overt and potential conflict of interest related to the publication of this article. (Copyright© GEOTAR-Media Publishing Group.)
Databáze:	MEDLINE
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