Differentiated Care Pathways for Antiretroviral Therapy Monitoring in Malawi: Expanding Viral Load Testing in Setting of Highly Prevalent Resistance.

Autor: Rutstein SE; Department of Health Policy and Management, University of North Carolina at Chapel Hill.; Division of Infectious Diseases, University of North Carolina at Chapel Hill., Compliment K; UNC Center for AIDS Research, University of North Carolina at Chapel Hill.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill., Nelson JAE; UNC Center for AIDS Research, University of North Carolina at Chapel Hill.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill., Kamwendo D; UNC Project, Lilongwe, Malawi., Mataya R; School of Public Health, Loma Linda University, California., Miller WC; Division of Infectious Diseases, University of North Carolina at Chapel Hill.; Department of Epidemiology, University of North Carolina at Chapel Hill., Hosseinipour MC; Division of Infectious Diseases, University of North Carolina at Chapel Hill.; UNC Project, Lilongwe, Malawi.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2017 Jun 19; Vol. 4 (3), pp. ofx125. Date of Electronic Publication: 2017 Jun 19 (Print Publication: 2017).
DOI: 10.1093/ofid/ofx125
Abstrakt: We quantified resistance to first-line antiretroviral therapy among previously unmonitored patients in Malawi with viremia (≥1000 copies/mL). Ninety-five percent (n = 57/61) harbored nucleoside/tide reverse transcriptase inhibitor/non-nucleoside reverse transcriptase inhibitor resistance; resistance was more common comparing >2 (97%) versus ≤2 years (87%) on therapy. Immediate switch for persons retained in care may improve monitoring efficiency and maximize clinical outcomes.
Databáze: MEDLINE