| Autor: |
Kern L; Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany. lara.kern@sf.mpg.de., Mittenbühler MJ; Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany. melanie.mittenbuehler@sf.mpg.de., Vesting AJ; Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany. Anna.Vesting@sf.mpg.de., Ostermann AL; Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany. anna.ostermann@sf.mpg.de., Wunderlich CM; Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany. claudia.wunderlich@sf.mpg.de., Wunderlich FT; Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), 50931 Cologne, Germany. thomas.wunderlich@sf.mpg.de. |
| Abstrakt: |
Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNFα and IL-6 signaling in hepatocellular carcinoma and colorectal cancers. |
