Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery.

Autor: Modica de Mohac L; DIBIMIS Department, University of Study of Palermo, 90128 Palermo, Italy. laura.modicademohac@unipa.it.; Drug Delivery Group, Institute of Pharmaceutical Science Faculty of Life Sciences and Medicine, King's College London, London SE1 9NH, UK. laura.modicademohac@unipa.it., Keating AV; Drug Delivery Group, Institute of Pharmaceutical Science Faculty of Life Sciences and Medicine, King's College London, London SE1 9NH, UK. Alison.Keating@kcl.ac.uk., de Fátima Pina M; Department of Pharmaceutics, University College London School of Pharmacy, London WC1N 1AX, UK. mariafatima.gpina@gmail.com., Raimi-Abraham BT; Drug Delivery Group, Institute of Pharmaceutical Science Faculty of Life Sciences and Medicine, King's College London, London SE1 9NH, UK. bahijja.raimi-abraham@kcl.ac.uk.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2018 Dec 24; Vol. 11 (1). Date of Electronic Publication: 2018 Dec 24.
DOI: 10.3390/pharmaceutics11010007
Abstrakt: Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.
Databáze: MEDLINE
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