Ameliorative Effects of Helianthus Annuus Against Nephrotoxic, Cardiac, and Haematological Disorders in Alloxan-induced Hyperglycaemia in Albino Rats.

Autor:	Onoja SO; Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture Umudike, PMB 7267, Umuahia Abia State, Nigeria., Udem SC; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Enugu State, Nigeria., Anaga AO; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Enugu State, Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of veterinary research [J Vet Res] 2018 Dec 10; Vol. 62 (3), pp. 371-377. Date of Electronic Publication: 2018 Dec 10 (Print Publication: 2018).
DOI:	10.2478/jvetres-2018-0053
Abstrakt:	Introduction: The study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats. Material and Methods: The cold maceration method with 80% methanol was used in the preparation of H . annuus extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A-E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, per os once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21. Results: The extract and glibenclamide significantly (P < 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan. Conclusion: H. annuus extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients. Competing Interests: Conflict of Interests Statement: The authors declare no conflict of interests regarding the publication of this article.
Databáze:	MEDLINE
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