A study of the association between UGT1A1*28 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer.

Autor: Anon B; Department of Hepatogastroenterology and Digestive Oncology, Tours, France. Electronic address: B.ANON@chu-tours.fr., Perray C; Department of Hepatogastroenterology and Digestive Oncology, Tours, France., Regnault D; Department of Hepatogastroenterology and Digestive Oncology, Tours, France., Caulet M; Department of Hepatogastroenterology and Digestive Oncology, Tours, France., Orain I; Department of Pathology, Tours, France., Godart B; Department of Hepatogastroenterology and Digestive Oncology, Tours, France., Pages JC; University of Tours, Tours, France., Tallet A; Platform of Somatic Tumour Molecular Genetics, Tours, France., Ouaissi M; Department of digestive surgery, Tours, France., Guyetant S; Department of Pathology, Tours, France., Barin-le Guellec C; University of Tours, Tours, France; Department of Molecular Biology, Tours, France; INSERM, UMR 1248, Université de Limoges, Limoges, France., Lecomte T; Department of Hepatogastroenterology and Digestive Oncology, Tours, France; EA 7501 (GICC), Université de Tours, France.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2019 Apr; Vol. 51 (4), pp. 579-583. Date of Electronic Publication: 2018 Dec 10.
DOI: 10.1016/j.dld.2018.11.032
Abstrakt: Introduction: The transcriptional activity of the UGT1A1 gene is modulated by a variable number of repetitions of the dinucleotide (TA) within its promoter region. By comparison to the most common allele (TA) 6 (UGT1A1*1), decreased activity is observed with increasing TA repetitions. The aim of this study was to determine whether the presence of the variant allele UGT1A1*28, harbouring seven TA repetitions, (TA) 7 , in the homozygous state, is associated with precancerous colonic lesions and/or with specific colorectal cancer characteristics.
Material and Methods: All patients treated for colorectal cancer in a tertiary care centre, between January 2009 and December 2013, who had routine UGT1A1 genotyping for irinotecan dose-adjustment were included. Data were retrospectively collected.
Results: 292 patients were enrolled, including 23 UGT1A1*28/*28 homozygous (7.9%), 137 wild type homozygous (46.9%) and 132 heterozygous (45.2%). There were no significant differences in phenotypic colonic characteristics between homozygous and heterozygous patients carrying the UGT1A1*28 allele as compared to *1/*1 homozygous. Patients treated with aspirin were significantly more common in the UGT1A1*28/*28 homozygous group than in the other groups (7/23 (30.4%) compared to 22/269 (8.2%), p = 0.001).
Conclusion: Dinucleotide polymorphism in the promoter region of the UGT1A1 gene is not associated with a specific colonic phenotype in patients with sporadic colorectal cancer.
(Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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