Association between Overweight/Obesity and Clinical Activity in Rheumatoid Arthritis.

Autor: Alvarez-Nemegyei J; Star Medica Merida Hospital, Mérida, Yucatán, México., Pacheco-Pantoja E; Medicine School, Health Sciences Division, Universidad Anáhuac Mayab, Mérida, Yucatán, México. Electronic address: elda.pacheco@anahuac.mx., González-Salazar M; Instituto Mexicano del Seguro Social, Delegación Yucatán, Mérida, Yucatán, México., López-Villanueva RF; Hospital Regional ISSSTE, Mérida, Yucatán, México., May-Kim S; Nutrition School, Universidad Anáhuac Mayab, Mérida, Yucatán, México., Martínez-Vargas L; Nutrition School, Universidad Anáhuac Mayab, Mérida, Yucatán, México., Quintal-Gutiérrez D; Nutrition School, Universidad Anáhuac Mayab, Mérida, Yucatán, México.
Jazyk: English; Spanish; Castilian
Zdroj: Reumatologia clinica [Reumatol Clin (Engl Ed)] 2020 Nov - Dec; Vol. 16 (6), pp. 462-467. Date of Electronic Publication: 2018 Dec 21.
DOI: 10.1016/j.reuma.2018.11.005
Abstrakt: Introduction: The effect of overweight/obesity on clinical status in rheumatoid arthritis (RA) is still a controversial topic.
Aim: To assess the association between body composition and clinical status in RA patients.
Methods: A prospective, comparative, cross-sectional study was performed on 123 (98.4% women, 86.3% FR+, 9.3±8.7 duration years) RA patients diagnosed according to ACR/EULAR 2010 criteria who were assessed for inflammatory activity (DAS 28), functional status (HAQ-Di), and type of treatment. Body composition was evaluated by BMI, waist, hip, and middle arm girths, waist/hip ratio, skin fold measurements, and bioelectrical impedance analysis.
Results: The prevalence of overweight and obesity (BMI-WHO cut-off points) was 30.9% and 45.5% respectively. Using Stavropoulos-Kalinoglou cut-off points, each corresponding prevalence increased to 31.7% and 58.5%, respectively. Pooled patients in the overweight/obesity classification (Stavropoulos-Kalinoglou classification) exhibited a significantly higher number of swollen joints as compared to subnormal/normal body composition subjects (3.8±3.3 vs. 1.9±2.5; p=.02). Swollen joint count showed significant positive correlation with 6 out of 11 body composition parameters: BMI; arm and hip girths, triceps skin fold, body fat average determined by bioelectrical impedance analysis, and skin fold measurements.
Conclusions: Prevalence of obesity in RA varies according to BMI cut-off points. Overweight and obesity were associated with higher inflammatory activity characterized by a higher count of tender and swollen joints. A positive correlation was found between swollen joint amount and the majority of the body fat mass indicators assessed. Body composition assessment/improvement should be an important part of the routine care of RA patients.
(Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
Databáze: MEDLINE
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