Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations.

Autor:	Kaali S; Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana. kaali.seyram@kintampo-hrc.org., Jack D; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA. dj2183@cumc.columbia.edu., Delimini R; Department of Biomedical Sciences, University of Health and Allied Sciences, P.O. Box 31, Ho, Ghana. rdelimini@uhas.edu.gh., Hu L; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA. lh2736@cumc.columbia.edu., Burkart K; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA. katburk@uw.edu., Opoku-Mensah J; Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana. jones.opoku-mensah@kintampo-hrc.org., Quinn A; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA. ashlinn.quinn@nih.gov., Ae-Ngibise KA; Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana. Kenneth.asayah@kintampo-hrc.org., Wylie B; Division of Maternal⁻fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. bwylie@bidmc.harvard.edu., Boamah-Kaali EA; Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana. ellen.boamah@kintampo-hrc.org., Chillrud S; Lamont-Doherty Earth Observatory at Columbia University, Palisades, NY 10964, USA. chilli@ldeo.columbia.edu., Owusu-Agyei S; Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana. sowusuagyei@uhas.edu.gh.; Institute of Health Research, University of Health and Allied Sciences, PMB 31, Ho, Ghana. sowusuagyei@uhas.edu.gh., Kinney PL; Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA. pkinney@bu.edu., Baccarelli AA; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA. andrea.baccarelli@columbia.edu., Asante KP; Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana. kwakupoku.asante@kintampo-hrc.org., Lee A; Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. alison.lee@mssm.edu.
Jazyk:	angličtina
Zdroj:	International journal of environmental research and public health [Int J Environ Res Public Health] 2018 Dec 22; Vol. 16 (1). Date of Electronic Publication: 2018 Dec 22.
DOI:	10.3390/ijerph16010026
Abstrakt:	Background: Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown. Materials and Methods: Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored. Results: LPG users had the lowest CO exposures ( p = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (β = -14.84, SE = 6.41, p = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG β = 19.34, SE = 9.72, p = 0.049), but especially boys (β = 30.65, SE = 14.46, p = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes. Conclusions: Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible.
Databáze:	MEDLINE
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