Indocyanine green molecular angiography of choroidal neovascularization.

Autor: Feenstra DJ; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Seleci M; Institute of Technical Chemistry, Leibniz University of Hanover, Hanover, Germany., Denk N; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Fauser S; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Drawnel FM; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Jayagopal A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., Basel, Switzerland. Electronic address: ashwath.jayagopal@roche.com.
Jazyk: angličtina
Zdroj: Experimental eye research [Exp Eye Res] 2019 Mar; Vol. 180, pp. 122-128. Date of Electronic Publication: 2018 Dec 21.
DOI: 10.1016/j.exer.2018.12.016
Abstrakt: Retinal diseases such as proliferative diabetic retinopathy and neovascular AMD are characterized by the formation of new blood vessels. Current imaging techniques such as fluorescein and ICG angiography help to identify areas of vascular leakage but are limited in their applicability due to their nonspecific nature. However, as new treatment paradigms emerge in an effort to have patient specific treatments, the development of new imaging techniques that are capable of identifying patient specific biomarkers will become crucial for the success of these approaches. In this study, we create and characterize an endoglin (CD105) targeted imaging probe that can be used for indocyanine green (ICG) molecular angiography. This anti-endoglin-ICG bioconjugate has a self-quenching "off-on" capacity to enable high contrast imaging of proliferative blood vessels at a molecular level in vivo. Using the laser CNV mouse model we demonstrate an approximate 3-fold increase in lesion visualization compared to non-targeting controls.
(Copyright © 2018. Published by Elsevier Ltd.)
Databáze: MEDLINE
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