RADIATION RISKS OF THYROID CANCER IN CHORNOBYL CLEAN-UP WORKERS USING THE ALTERNATIVE ESTIMATES OF DOSES OF EXTERNAL EXPOSURE.

Autor:	Prysyazhnyuk AY; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Trotsyuk NK; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Gudzenko NA; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Chumak VV; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Bakhanova OV; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Fuzik MM; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Belyaev YM; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Fedorenko ZP; National Cancer Institute, 33/34, Lomonosov str., Kyiv, 03022, Ukraine., Gorokh YL; National Cancer Institute, 33/34, Lomonosov str., Kyiv, 03022, Ukraine., Romanenko AY; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Bazyka DA; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine., Khukhryanska OM; State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53, Melnykov str., Kyiv, 04050, Ukraine.
Jazyk:	English; Ukrainian
Zdroj:	Problemy radiatsiinoi medytsyny ta radiobiolohii [Probl Radiac Med Radiobiol] 2018 Dec; Vol. 23, pp. 200-215.
DOI:	10.33145/2304-8336-2018-23-200-215
Abstrakt:	Objective: The objective of this study was to estimate the thyroid cancer radiation risks - excess absolute risk(EAR), excess relative risk (ERR) and attributable fraction of risk (AR) in the cohort of 150,813 Ukrainian male clean-up workers during the 1986-2012 period (more than 25 years after the Chornobyl accident). Materials and Methods: The cohort under study of 150,813 Ukrainian men who participated emergency and clean-up work in 1986-1990 was formed based on the data of the Ukrainian State Register of persons affected due toChornobyl accident (SRU). The identification of thyroid cancer cases (216) was carried out by linking the SRU data-base with the National Cancer Registry of Ukraine (NCRU) data. Standardised incidence ratios (SIR) were estimatedcomparing thyroid cancer incidence in the cohort with the corresponding national indices. Excess absolute risk(EAR), excess relative risk (ERR) and attributable fraction of risk (AR) were calculated accounting for the alterna-tive dose estimates. The following sources of the average dose values for Ukrainian liquidators were used: officialtotal external dose records according to UNSCEAR 2008 report and results of external red bone marrow dose recon-struction by the RADRUE method for the cohort sample. For the radiation risk evaluation, these estimates were con-versed to the average external thyroid dose. Results: Results of the long term study (1986-2012) of thyroid cancer risks in a cohort of 150813 Chornobyl clean-up workers («liquidators») from Ukraine are presented. Two options for the average thyroid dose estimates were usedfor radiation risks evaluation. According to the SRU and NCRU 216 incident thyroid cancers were diagnosed in 1986-2012 within the studied cohort with an overall SIR of 3.35 (95 % confidence interval (CI) 2.51-3.80). The SIR esti-mates were elevated throughout the entire follow-up period. Investigation of a contribution of the external expo-sure (according to the alternative values) showed the elevated dose associated thyroid cancer rates in the studiedcohort. Alternatively estimated EAR/104 PY Gy were of 1.86 (95 % CI 0.47-3.24) and 2.07 (95 % CI 0.53-3.62);ERR/Gy - 2.38 (95 % CI 0.60-4.15) and 2.66 (95 % CI 0.68-4.64) and AR % (Gy) 70.4 % and 72.7 % Gy. Conclusions: Obtained results prove the dose dependent increase of thyroid cancer incidence among UkrainianChornobyl clean-up workers. These conclusions are consistent with those received for combined cohort of Belarus,Russia and Baltic States liquidators. (A. Ye. Prysyazhnyuk, N. K. Trotsyuk, N. A. Gudzenko, V. V. Chumak, O. V. Bakhanova, M. M. Fuzik, Yu. M. Belyaev, Z. P. Fedorenko, Y. L. Gorokh, A. Yu. Romanenko, D. A. Bazyka, O. M. Khukhryanska.)
Databáze:	MEDLINE
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