| Autor: |
Ghaedian MM; Department of cardiology, Jiroft University of Medical Sciences, Jiroft, Iran., Nazari Jaz A; Medical School, Jiroft University of Medical Sciences, Jiroft, Iran., Momeni M; Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran., Ghaedian T; Nuclear medicine and Molecular ImagingResearch Center, NamaziTeaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran., Samiei N; Medical School, Jiroft University of Medical Sciences, Jiroft, Iran. |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2020; Vol. 42 (1), pp. 31-35. Date of Electronic Publication: 2018 Dec 22. |
| DOI: |
10.1080/10641963.2018.1557684 |
| Abstrakt: |
Background : Since the introduction of leptin, many studies suggest an important role for this hormone in obesity-related hypertension. However, in non-obese patients, there are controversial results regarding the possible role of leptin in essential hypertension especially in both sexes and different groups of body mass index (BMI). We aimed to evaluate the association of leptin and hypertension in both female and male gender. Materials and Methods : This cross-sectional study was conducted, recruiting 80 essential hypertensive patients and 80 healthy normotensive volunteers using convenience sampling method. Subjects without history of diabetes mellitus, hyperlipidemia, smoking, thyroid disease and insulin or corticosteroid use were included in two groups of normotensive and hypertensive subjects who were matched for age, sex and BMI. Systolic and diastolic blood pressure (SBP and DBP), weight and height were measured for all subjects and a blood sample was obtained for measurement of leptin, fasting blood sugar and lipid profiles. Results : Leptin was significantly higher in hypertensive patients as compared to normotensive subjects in all study population and both male and female subgroups (p < 0.001). Statistically significant correlation was also found between leptin and both SBP and DBP in above-mentioned subgroups. In comparison of controlled and uncontrolled hypertensive patients, leptin was significantly higher in uncontrolled hypertensive patients (p < 0.001). Conclusion : Comparing two groups of hypertensive and normotensive subjects, leptin is found to be positively correlated with hypertension in both genders. Leptin level also tends to be higher in uncontrolled hypertensive patients which may indicate a possible role for leptin in mechanism of uncontrolled hypertension. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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