| Autor: |
Bennett RM; Division of Arthritis and Rheumatic Diseases, Oregon Health Sciences University, Portland 97201., Gatter RA, Campbell SM, Andrews RP, Clark SR, Scarola JA |
| Jazyk: |
angličtina |
| Zdroj: |
Arthritis and rheumatism [Arthritis Rheum] 1988 Dec; Vol. 31 (12), pp. 1535-42. |
| DOI: |
10.1002/art.1780311210 |
| Abstrakt: |
The efficacy of cyclobenzaprine (Flexeril), as compared with placebo, was tested in a 12-week, double-blind, controlled trial of 120 patients with fibrositis. Of the patients who received placebo, 52% dropped out due to lack of efficacy of the drug, compared with 16% of patients taking cyclobenzaprine. The dropout rate due to adverse reactions was similar in the 2 groups. Patients taking cyclobenzaprine experienced a significant decrease in the severity of pain and a significant increase in the quality of sleep. There was a trend toward improvement in the symptoms of fatigue, but morning stiffness was not alleviated. These improvements in symptoms were associated with a significant reduction in the total number of tender points and in muscle tightness. Our findings indicate that cyclobenzaprine is a useful adjunct in treating patients with the fibrositis syndrome. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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