Cardiac function is not associated with glucose control in older women.

Autor: Jones C; Cardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Newcastle University, UK., Markovic M; Faculty of Sport and Physical Education, University of Belgrade, Serbia., Charman S; Cardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Newcastle University, UK., Okwose N; Cardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Newcastle University, UK., Ivkovic S; Faculty of Medical Sciences, Centre for Rehabilitation, University of Pristina and Clinical Centre, Kosovska Mitrovica, Serbia., Ropret R; Faculty of Sport and Physical Education, University of Belgrade, Serbia., Markovic B; Faculty of Sport and Physical Education, University of Belgrade, Serbia., Mandaric S; Faculty of Sport and Physical Education, University of Belgrade, Serbia., Grbovic M; Faculty of Sport and Physical Education, University of Belgrade, Serbia., MacGowan GA; Cardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Newcastle University, UK; Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Jakovljevic DG; Cardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Newcastle University, UK; Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; RCUK Newcastle Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. Electronic address: djordje.jakovljevic@newcastle.ac.uk.
Jazyk: angličtina
Zdroj: Experimental gerontology [Exp Gerontol] 2019 Feb; Vol. 116, pp. 31-36. Date of Electronic Publication: 2018 Dec 20.
DOI: 10.1016/j.exger.2018.12.014
Abstrakt: The present study evaluated the effect of age on glucose tolerance and cardiac function and assessed the relationship between metabolic control and cardiac function and performance. Thirty-four healthy women aged 40 to 81 years were divided into two age groups: younger (≤50 years of age, N = 19) and older (≥60 years of age, N = 15). Participants performed an oral glucose tolerance test and a graded cardiopulmonary exercise test with non-invasive haemodynamic measurements. Compared to younger, older women demonstrated significantly higher 2-hour glucose (4.67 ± 1.01 vs 6.08 ± 1.54 mmol/l, P < 0.01), but lower peak exercise O 2 consumption (1.96 ± 0.44 vs 1.38 ± 0.26 l/min, P < 0.01) and cardiac power output (4.06 ± 0.76 vs 3.35 ± 0.73 W, P = 0.01). When data from all study participants were combined, there was a significant negative relationship between 2-hour glucose and peak cardiac power (r = -0.39, P = 0.02), and peak O 2 consumption (r = -0.40, P = 0.02). The strength of these relationships was affected by age, with moderate negative relationship identified between 2-hour glucose and peak cardiac power output in younger compared to older participants (r = -0.38, P = 0.11 vs. r = -0.09, P = 0.75). Metabolic control and cardiac function decline with age. The lack of relationship between glucose control and cardiac power may suggest that metabolic control does not influence cardiac function and performance in older women.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: