Regulation of Ca 2+ signaling by acute hypoxia and acidosis in cardiomyocytes derived from human induced pluripotent stem cells.
Autor: | Fernández-Morales JC; Cardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, USA., Hua W; Cardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, USA., Yao Y; Cardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, USA., Morad M; Cardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, USA; Department of Pharmacology,Georgetown University Medical Center, Washington, DC, USA. Electronic address: moradm@musc.edu. |
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Jazyk: | angličtina |
Zdroj: | Cell calcium [Cell Calcium] 2019 Mar; Vol. 78, pp. 1-14. Date of Electronic Publication: 2018 Dec 12. |
DOI: | 10.1016/j.ceca.2018.12.006 |
Abstrakt: | Aims: The effects of acute (100 s) hypoxia and/or acidosis on Ca 2+ signaling parameters of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are explored here for the first time. Methods and Results: 1) hiPSC-CMs express two cell populations: rapidly-inactivating I Conclusions: Variability in I (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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