Long-Term Gynecological Cancer Survivors in Côte d'Or: Health-Related Quality of Life and Living Conditions.

Autor: Mamguem Kamga A; Breast and Gynecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France.; Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France., Dumas A; Centre for Research in Epidemiology and Population Health (CESP), INSERM U1018, Université Paris-Sud, University of Paris-Saclay, Villejuif, France and Department of Clinical Research, Gustave Roussy, INSERM U1018, B2M, Villejuif, France., Joly F; University Hospital Côte de Nacre, François Baclesse Comprehensive Cancer Centre, Medical Oncology Department, INSERM U1086, Caen, France., Billa O; Breast and Gynecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France.; Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France., Simon J; Breast and Gynecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France., Poillot ML; Breast and Gynecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France., Darut-Jouve A; Centre Radiothérapie du Parc, Dijon, France., Coutant C; Medical Oncology, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France.; Burgundy Franche-Comté University, Dijon, France., Fumoleau P; Burgundy Franche-Comté University, Dijon, France.; Curie Institute, Paris, France., Arveux P; Breast and Gynecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France.; Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France., Dabakuyo-Yonli TS; Breast and Gynecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre-UNICANCER, Dijon, France sdabakuyo@cgfl.fr.; Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France.; National Quality of Life and Cancer Clinical Research Platform, Dijon, France.
Jazyk: angličtina
Zdroj: The oncologist [Oncologist] 2019 Jul; Vol. 24 (7), pp. e490-e500. Date of Electronic Publication: 2018 Dec 21.
DOI: 10.1634/theoncologist.2018-0347
Abstrakt: Background: The likelihood that health-related quality of life (HRQoL) could depend on factors other than clinical data increases with the duration of follow-up since diagnosis. The aim of this study was to identify determinants of long-term HRQoL in women with cervical, endometrial, and ovarian cancer. Secondary objectives were to describe their living conditions (sexual function, psychological distress, social and professional reinsertion).
Materials and Methods: In a cross-sectional survey, women diagnosed with cervical, endometrial, and ovarian cancers from 2006 to 2013 were selected through the French gynecological cancers registry of Côte d'Or. Validated questionnaires exploring HRQoL (short-form health survey; SF-12), anxiety and depression (Hospital Anxiety and Depression Scale), social support (Sarason's Social Support Questionnaire), sexual function (Female Sexual Function Index), and living conditions (EPICES questionnaire) were used to assess HRQoL and its determinants. Social and professional reinsertion were also investigated using study-specific questionnaires. Determinants of HRQoL were identified using a multivariable mixed-regression model for each composite score of the SF-12.
Results: In total, 195 gynecological cancer survivors participated in the survey. HRQoL was deteriorated for almost all the SF-12 dimensions. The main determinants of poor HRQoL were comorbidities, deprivation, lack of availability and satisfaction with social support, and psychological outcomes. Thirty-four percent of survivors of gynecological cancer reported a negative impact of cancer on their work, and 73% reported an impaired ability to work after treatment.
Conclusions: Long-term HRQoL of survivors of gynecological cancer is not impacted by stage of disease. Specific interventions should focus on issues that promote social and professional reintegration and improve HRQoL.
Implications for Practice: This study shows that women with gynecological cancer have problems related to work and sexual dysfunction, even 5 years after diagnosis. The results of this study will help improve clinicians' awareness of the factors affecting the lives of gynecological cancer survivors, even long after diagnosis and treatment. They will also highlight for clinicians the areas that are of importance to gynecological cancer survivors, making it possible to guide management of these patients with a view to preventing deteriorated health-related quality of life after treatment. For the health authorities, the results of this study underline that more than 5 years after gynecological cancer, the initial stage of disease no longer affects quality of life, but there is a clear need for actions targeting socio-professional reintegration of survivors.
Competing Interests: Disclosures of potential conflicts of interest may be found at the end of this article.
(© AlphaMed Press 2018.)
Databáze: MEDLINE
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