Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men.

Autor: Jefferis BJ; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK. Electronic address: b.jefferis@ucl.ac.uk., Parsons TJ; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK., Sartini C; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK., Ash S; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK., Lennon LT; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK., Papacosta O; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK., Morris RW; Population Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK., Wannamethee SG; Department of Primary Care & Population Health, University College London, Rowland Hill Street, London, NW3 2PF, UK., Lee IM; Harvard Medical School, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA02215, USA., Whincup PH; Population Health Research Institute, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2019 Mar 01; Vol. 278, pp. 267-272. Date of Electronic Publication: 2018 Dec 13.
DOI: 10.1016/j.ijcard.2018.12.024
Abstrakt: Aims: With increasing age, physical inactivity and sedentary behaviour levels increase, as does cardiovascular disease (CVD) incidence. We investigate how device-measured sedentary behaviour and physical activity (PA) are related to CVD onset in men aged 70+; whether the total volume of activity is more important than pattern.
Methods and Results: Prospective population-based cohort study of men recruited from 24 UK General Practices in 1978-80. In 2010-12, 3137 survivors were invited to complete questionnaires and wear an Actigraph GT3x accelerometer for 7 days. PA intensity was categorised as sedentary, light and moderate to vigorous (MVPA). Men were followed up for Myocardial Infarction, stroke and heart failure (ICD9 410-414, 430-438 and 428) morbidity and mortality from 2010 to 12 to June 2016. Hazard Ratios (HRs) for incident Cardiovascular Disease (CVD) were estimated. 1528/3137 (49%) men had sufficient accelerometer data. 254 men with pre-existing CVD were excluded. Participants' mean age was 78.4 (range 71-92) years. After median 4.9 years follow-up, 122 first CVD events occurred in 1181 men (22.7/1000 person-years) with complete data. For each additional 30 min in sedentary behaviour, light PA,10 min in MVPA, or 1000 steps/day, HRs for CVD were 1.09(95%CI 1.00, 1.19), 0.94(0.85, 1.04), 0.88(0.81, 0.96) and 0.86(0.78 to 0.95) respectively, adjusted for measurement-related factors, socio-demographics, health behaviours and disability. HRs for accumulating 150 min/week MVPA in bouts ≥1 min and bouts ≥10 min were 0.47(0.32 to 0.69), and 0.49(0.25, 0.98).
Conclusions: In older men, high volume of steps or MVPA rather than MVPA bouts was associated with reduced CVD risk.
(Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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