Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia.

Autor: Efficace F; Italian Group for Adult Hematologic Diseases (GIMEMA), Data Center and Health Outcomes Research Unit, Rome, Italy. f.efficace@gimema.it., Breccia M; Department of Cellular Biotechnologies and Hematology, 'Sapienza' University of Rome, Rome, Italy., Avvisati G; Hematology and Stem Cell Transplantation Unit, University Campus Bio-Medico, Rome, Italy., Cottone F; Italian Group for Adult Hematologic Diseases (GIMEMA), Data Center and Health Outcomes Research Unit, Rome, Italy., Intermesoli T; University of Milan, Hematology and BMT Unit, ASST Papa Giovanni XXIII, Bergamo, Italy., Borlenghi E; Department of Hematology, ASST Spedali Civili, Brescia, Italy., Carluccio P; Hematology Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy., Rodeghiero F; Hematology Project Foundation, Department of Hematology, San Bortolo Hospital, Vicenza, Italy., Fabbiano F; Division of Hematology and Bone Marrow Transplantation, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy., Luppi M; Department of Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico, University of Modena and Reggio Emilia, Modena, Italy., Romani C; U.O. Ematologia e Centro TMO, Ospedale Armando Businco, Cagliari, Italy., Sborgia M; Department of Hematology, Bone Marrow Transplant Center, Pescara, Italy., D'Ardia S; Division of Hematology, Città della Salute e della Scienza Hospital, Turin, Italy., Nobile F; Hematology Unit, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy., Cantore N; Hematology and Hematopoietic Transplantation Unit, San G. Moscati Hospital, Avellino, Italy., Crugnola M; Hematology, Parma University, Parma, Italy., Nadali G; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy., Vignetti M; Italian Group for Adult Hematologic Diseases (GIMEMA), Data Center and Health Outcomes Research Unit, Rome, Italy., Amadori S; Italian Group for Adult Hematologic Diseases (GIMEMA), Data Center and Health Outcomes Research Unit, Rome, Italy., Lo Coco F; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Jazyk: angličtina
Zdroj: Leukemia [Leukemia] 2019 Jul; Vol. 33 (7), pp. 1598-1607. Date of Electronic Publication: 2018 Dec 20.
DOI: 10.1038/s41375-018-0325-4
Abstrakt: The objective of this study was to investigate health-related quality of life (HRQOL), symptom burden, and comorbidity profile in long-term acute promyelocytic leukemia (APL) survivors treated with standard chemotherapy. Overall, 307 long-term APL survivors were invited to participate. HRQOL was assessed with the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and compared with that of age and sex-matched controls from the general population. Symptom burden was assessed with the MD Anderson Symptom Inventory (MDASI) questionnaire and comorbidity profile was also investigated. Median follow-up time since diagnosis was 14.3 years (interquartile range: 11.1-16.9 years). APL survivors had a statistically and clinically meaningful worse score for the role physical scale of the SF-36 (-9.5; 95% CI, -15.7 to -3.2, P = 0.003) than their peers in the general population. Fatigue was reported as moderate to severe by 29% of patients and 84.4% reported at least one comorbidity. Prevalence of comorbidity in APL survivors was higher than that reported by the general population. Also, marked variations were found in the HRQOL profile by number of comorbidities. Even many years after treatment ends, APL survivors treated with standard chemotherapy do not fully recover as they report HRQOL limitations and a substantial burden of symptoms.
Databáze: MEDLINE
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