Prefrontal-Bed Nucleus Circuit Modulation of a Passive Coping Response Set.

Autor:	Johnson SB; Interdisciplinary Neuroscience Program., Emmons EB; Interdisciplinary Neuroscience Program., Lingg RT; Department of Psychological and Brain Sciences., Anderson RM; Department of Psychological and Brain Sciences., Romig-Martin SA; Department of Psychological and Brain Sciences., LaLumiere RT; Interdisciplinary Neuroscience Program.; Department of Psychological and Brain Sciences.; Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, and., Narayanan NS; Interdisciplinary Neuroscience Program.; Department of Neurology, Carver College of Medicine.; Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, and., Viau V; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada., Radley JJ; Interdisciplinary Neuroscience Program, jason-radley@uiowa.edu.; Department of Psychological and Brain Sciences.; Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, and.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 Feb 20; Vol. 39 (8), pp. 1405-1419. Date of Electronic Publication: 2018 Dec 20.
DOI:	10.1523/JNEUROSCI.1421-18.2018
Abstrakt:	One of the challenges facing neuroscience entails localization of circuits and mechanisms accounting for how multiple features of stress responses are organized to promote survival during adverse experiences. The rodent medial prefrontal cortex (mPFC) is generally regarded as a key site for cognitive and affective information processing, and the anteroventral bed nuclei of the stria terminalis (avBST) integrates homeostatic information from a variety of sources, including the mPFC. Thus, we proposed that the mPFC is capable of generating multiple features (endocrine, behavioral) of adaptive responses via its influence over the avBST. To address this possibility, we first optogenetically inhibited input to avBST from the rostral prelimbic cortical region of mPFC and observed concurrent increases in immobility and hypothalamo-pituitary-adrenal (HPA) output in male rats during tail suspension, whereas photostimulation of this pathway decreased immobility during the same challenge. Anatomical tracing experiments confirmed projections from the rostral prelimbic subfield to separate populations of avBST neurons, and from these to HPA effector neurons in the paraventricular hypothalamic nucleus, and to aspects of the midbrain periaqueductal gray that coordinate passive defensive behaviors. Finally, stimulation and inhibition of the prelimbic-avBST pathway, respectively, decreased and increased passive coping in the shock-probe defensive burying test, without having any direct effect on active coping (burying) behavior. These results define a new neural substrate in the coordination of a response set that involves the gating of passive, rather than active, coping behaviors while restraining neuroendocrine activation to optimize adaptation during threat exposure. SIGNIFICANCE STATEMENT The circuits and mechanisms accounting for how multiple features of responses are organized to promote adaptation have yet to be elucidated. Our report identifies a prefrontal-bed nucleus pathway that organizes a response set capable of gating passive coping behaviors while concurrently restraining neuroendocrine activation during exposure to inescapable stressors. These data provide insight into the central organization of how multiple features of responses are integrated to promote adaptation during adverse experiences, and how disruption in one neural pathway may underlie a broad array of maladaptive responses in stress-related psychiatric disorders. (Copyright © 2019 the authors 0270-6474/19/391405-15$15.00/0.)
Databáze:	MEDLINE
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