Maternal and post-natal obesity alters long-term memory and hippocampal molecular signaling of male rat.

Autor: Mucellini AB; Graduate Program of Psychiatry and Behavioral Sciences, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Graduate Program of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: amandabmuc@gmail.com., Laureano DP; Graduate Program of Neuroscience, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Silveira PP; Graduate Program of Neuroscience, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Psychiatry, Faculty of Medicine and Sackler Institute for Epigenetics & Psychobiology at McGill University, Ludmer Centre for Neuroinformatics and Mental Health, Douglas Hospital Research Centre, Montreal, QC, Canada., Sanvitto GL; Graduate Program of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2019 Apr 01; Vol. 1708, pp. 138-145. Date of Electronic Publication: 2018 Dec 17.
DOI: 10.1016/j.brainres.2018.12.021
Abstrakt: The aim of this study was to investigate whether maternal cafeteria ingestion interferes with long-term memory-related behaviors and hippocampal brain-derived neurotrophic factor (BDNF) signaling in the offspring, and if there is a cumulative effect with the exposure to cafeteria diet during the life-course of the pups. Female rats were fed a control (CON, n = 20) or cafeteria diet (CAF, n = 24) from their weaning to weaning of their offspring. After that, their male offspring were divided into 4 groups (CON-CON, n = 36; CON-CAF, n = 38, CAF-CON, n = 46 and CAF-CAF, n = 39) so that all litters ingested CON or CAF, irrespective of maternal diet. At 30 days of age, all groups exposed to cafeteria diet at some stage in life showed a decline in performance on one or both object recognition and inhibitory avoidance tasks. At 120 days, CON-CAF and CAF-CAF groups continued to show memory impairment. There were no significant differences between groups in the hippocampal concentrations of BDNF and cAMP Response Element Binding protein (CREB) in puberty or adulthood, but the concentration of hippocampal Ras-Raf-MEK-mitogen-activated protein kinase (MAPK) was higher in CAF-CAF pubescent offspring when compared to the CON-CON group. These data suggest that maternal diet affects the behavior and the molecular signaling related to long-term memory of the offspring, and that its effects are influenced by postnatal diet.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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