Trichomonicidal activity of a new anthraquinone isolated from the roots of Morinda panamensis Seem.

Autor: Cáceres-Castillo D; Laboratorio de Química Farmacéutica. Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatan, Mexico., Pérez-Navarro Y; Posgrado de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, D.F., Mexico., Torres-Romero JC; Laboratorio de Bioquímica y Genética Molecular. Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatan, Mexico., Mirón-López G; Laboratorio de Química Farmacéutica. Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatan, Mexico., Ceballos-Cruz J; Laboratorio de Química Farmacéutica. Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatan, Mexico., Arana-Argáez V; Laboratorio de Farmacología. Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatan, Mexico., Vázquez-Carrillo L; Posgrado de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, D.F., Mexico., Fernández-Sánchez JM; Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, Mexico., Alvarez-Sánchez ME; Posgrado de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, D.F., Mexico.
Jazyk: angličtina
Zdroj: Drug development research [Drug Dev Res] 2019 Feb; Vol. 80 (1), pp. 155-161. Date of Electronic Publication: 2018 Dec 20.
DOI: 10.1002/ddr.21504
Abstrakt: Trichomoniasis, caused by the protozoan parasite Trichomonas vaginalis, is the most common nonviral sexually transmitted infection worldwide. Although drug treatment is available, unpleasant side effects and increased resistance to the nitroimidazole family have been documented. Hence, there is a need for the identification of new and safe therapeutic agents against T. vaginalis. Antimicrobial activity of anthraquinone compounds has been reported by a number of authors. The genus Morinda is well known for the diversity of anthraquinones with numerous biological activities. A new anthraquinone, lucidin-ω-isopropyl ether, was isolated from the roots of Morinda panamensis Seem. The structure of the compound was determined by 1 H and 13 C Nuclear Magnetic Resonance (NMR) analyses, in addition to comparison with literature reports. Using in vitro susceptibility assay, the half inhibitory concentration (IC 50 ) of lucidin-ω-isopropyl ether for T. vaginalis (1.32 μg/mL) was found similar to that of metronidazole concentration tested (6 μM = 1.03 μg/mL). In addition, this anthraquinone was capable of inhibiting the parasite's ability to kill HeLa cells and decreased proteolytic activity of the proteinase TvMP50 from T. vaginalis. This was associated with the decreased expression of the mp50 gene. These results demonstrate the trichomonicidal potential by lucidin-ω-isopropyl ether. Further action-mode studies are necessary to elucidate the antiparasitic mechanism of this new anthraquinone to develop a more potent antitrichomonal agent.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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