Health-related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients.

Autor: Yuen WY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan A; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Karthik SV; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Quak SH; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kow AW; Department of Surgery, National University Health System, Singapore, Singapore., Aw MM; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Pediatric transplantation [Pediatr Transplant] 2019 Mar; Vol. 23 (2), pp. e13337. Date of Electronic Publication: 2018 Dec 19.
DOI: 10.1111/petr.13337
Abstrakt: Purpose: The understanding of the HRQOL issues for parent donors of children who underwent LDLT is lacking. We evaluated the HRQOL of donor and non-donor parents, described their subjective experiences and identified factors associated with lower HRQOL post-donation.
Methods: This is a cross-sectional study of parent donors whose children underwent LDLT, using SF-36v2 Health Survey to measure HRQOL, and a self-developed questionnaire to evaluate their subjective experiences.
Results: Of 32 pairs of donor and non-donor parents, 27 donor and 19 non-donor parents responded. The data of respondents were analyzed. Both donor and non-donor parents' SF-36v2 norm-based scores were average or above average as compared to the Singapore population. Donors who made lifestyle changes post-donation (adopting a healthy balanced diet, regular physical activity, quitting smoking, and moderate alcohol intake) were associated with lower GH (P = 0.009) and PF (P = 0.002) scores. Donors who took more than 3 months for full recovery had lower RP (P = 0.022) and BP scores (P = 0.038). On multivariate analysis, recipient complication of Clavien grade 3 or 4 was associated with increased RP score by 8.71 points (95% CI: 1.74-15.68), after adjusting for time taken for full recovery. Majority (88.8%) had self-reported recovery time under 6 months and returned to work within 3 months (74.0%).
Conclusions: Donors with factors potentially associated with lower HRQOL may need more support to ensure better HRQOL outcomes post-donation.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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