Genetic associations of inflammatory bowel disease in a South Asian population.

Autor:	Niriella MA; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka. maduniln@yahoo.co.uk., Liyanage IK; Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda 10250, Sri Lanka., Kodisinghe SK; University Medical Unit, Colombo North Teaching Hospital, Ragama 0025, Sri Lanka., Silva AP; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka., Rajapakshe N; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka., Nanayakkara SD; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka., Luke D; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka., Silva T; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka., Nawarathne M; Gastroenterology Unit, National Hospital of Sri Lanka, Colombo 0010, Sri Lanka., Peiris RK; Gastroenterology Unit, Colombo South Teaching Hospital, Kalubovila 80000, Sri Lanka., Kalubovila UP; Gastroenterology Unit, Teaching Hospital Kandy, Kandy 20400, Sri Lanka., Kumarasena SR; Gastroenterology Unit, Teaching Hospital Karapitiya, Galle 80000, Sri Lanka., Dissanayake VHW; Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 0010, Sri Lanka., Jayasekara RW; Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo 0010, Sri Lanka., de Silva HJ; Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2018 Dec 06; Vol. 6 (15), pp. 908-915.
DOI:	10.12998/wjcc.v6.i15.908
Abstrakt:	Aim: To estimate prevalence and phenotypic associations of selected inflammatory bowel disease (IBD)-associated genetic variants among Sri Lankan patients. Methods: A case study of histologically confirmed ulcerative colitis (UC) or Crohn's disease (CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12B : rs1045431 , IL23R : rs11805303 , ARPC2 : rs12612347 , IRGM : rs13361189 , IL26 / IL22 : rs1558744 , CDH1 : rs1728785 , IL10 : rs3024505 , FCGR2A : rs3737240 , PTGER4 : rs4613763 , IL17REL / PIM3 : rs5771069 , HNF4a : rs6017342 , STAT3 : rs744166 , SMURF1 : rs7809799 , LAMB1 : rs886774 , HLA-DRB5 , DQA1 , DRB1 , DRA : rs9268853 , MST1 , UBA7 , and APEH : rs9822268 . The genotypes of all variants were in Hardy-Weinberg Equilibrium ( P > 10 -3 ). To account for multiple hypothesis testing, P -values < 0.003 were considered significant. Results: A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms (SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774 ( LAMB1 -gene) and UC (odds ratio (OR) = 1.42, P = 0.001). UC patients with rs886774 had mild disease (OR = 1.66, P < 0.001) and remained in remission (OR = 1.48, P < 0.001). A positive association was noted between rs10045431 ( IL 12B gene) and upper gastrointestinal involvement in CD (OR = 4.76, P = 0.002). Conclusion: This confirms the heterogeneity of allelic mutations in South Asians compared to Caucasians. Most SNPs and disease associations reported here have not been described in South Asians. Competing Interests: Conflict-of-interest statement: All authors declare that there are no conflicts of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu