| Autor: |
Seyama S; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences., Nishioka H; Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Nakaminami H; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences., Nakase K; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences., Wajima T; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences., Hagi A; Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Noguchi N; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences. |
| Jazyk: |
angličtina |
| Zdroj: |
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2019 Mar 01; Vol. 42 (3), pp. 512-515. Date of Electronic Publication: 2018 Dec 20. |
| DOI: |
10.1248/bpb.b18-00821 |
| Abstrakt: |
Recently, 1.5% olanexidine gluconate, a biguanide compounds, was launched as a new antiseptic agent in Japan. However, the comprehensive bactericidal spectrum of olanexidine gluconate is still unknown. In this study, we evaluated in vitro bactericidal activity of olanexidine gluconate using time-kill assay against various bacteria, mycobacteria, and fungi. With the exception of Burkholderia cepacia and Mycobacterium spp., 1.5% olanexidine gluconate exhibited fast-acting (≤60 s) bactericidal activity against all tested Gram-positive and Gram-negative bacteria, including vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, extended spectrum β-lactamase producing Klebsiella pneumoniae, and multidrug-resistant Pseudomonas aeruginosa. Furthermore, 1.5% olanexidine gluconate eradicated Candida albicans, Microsporum canis, and Malassezia furfur within 3 min. Our findings indicate that olanexidine gluconate has broad spectrum bactericidal activity; therefore, it may be useful for the prevention of a wide range of infectious diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
