Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis.

Autor:	Kariholu U; Centre for Perinatal Neuroscience, Imperial College London, London, UK.; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Montaldo P; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Markati T; Centre for Perinatal Neuroscience, Imperial College London, London, UK.; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Lally PJ; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Pryce R; Centre for Perinatal Neuroscience, Imperial College London, London, UK.; Neonatal Unit, Medway Hospital NHS Trust, Gillingham, UK., Teiserskas J; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Liow N; Neonatal Unit, Imperial College Healthcare NHS Trust, London, UK., Oliveira V; Centre for Perinatal Neuroscience, Imperial College London, London, UK., Soe A; Neonatal Unit, Medway Hospital NHS Trust, Gillingham, UK., Shankaran S; Neonatal Perinatal Medicine, Wayne State University, Detroit, Michigan, USA., Thayyil S; Centre for Perinatal Neuroscience, Imperial College London, London, UK.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2020 Mar; Vol. 105 (2), pp. 225-228. Date of Electronic Publication: 2018 Dec 19.
DOI:	10.1136/archdischild-2018-315711
Abstrakt:	Objectives: To examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE). Data Source: MEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using 'hypoxic ischaemic encephalopathy', 'newborn' and 'hypothermia', and 'clinical trials' as medical subject headings and terms. Manual search of the reference lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles. Study Selection: Randomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care. Data Extraction: Safety and efficacy data extracted independently by two reviewers and analysed. Results: We included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta-analysis. Adverse outcomes occurred in 11/56 (19.6%) of the cooled babies and 12/61 (19.7%) of the usual care babies (risk ratio 1.11 (95% CIs 0.55 to 2.25)). Conclusions: Current evidence is insufficient to recommend routine therapeutic hypothermia for babies with mild encephalopathy and significant benefits or harm cannot be excluded. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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