Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.

Autor: Pothuraju R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA., Rachagani S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA., Junker WM; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.; Sanguine Diagnostics and Therapeutics, University of Nebraska Medical Center, Omaha, NE, USA., Chaudhary S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA., Saraswathi V; Department of Cellular & Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA., Kaur S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA., Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. sbatra@unmc.edu.; Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. sbatra@unmc.edu.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. sbatra@unmc.edu.
Jazyk: angličtina
Zdroj: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2018 Dec 19; Vol. 37 (1), pp. 319. Date of Electronic Publication: 2018 Dec 19.
DOI: 10.1186/s13046-018-0963-4
Abstrakt: Background: Pancreatic cancer (PC) is among foremost causes of cancer related deaths worldwide due to generic symptoms, lack of effective screening strategies and resistance to chemo- and radiotherapies. The risk factors associated with PC include several metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (T2DM). Studies have shown that obesity and T2DM are associated with PC pathogenesis; however, their role in PC initiation and development remains obscure.
Main Body: Several biochemical and physiological factors associated with obesity and/or T2DM including adipokines, inflammatory mediators, and altered microbiome are involved in PC progression and metastasis albeit by different molecular mechanisms. Deep understanding of these factors and causal relationship between factors and altered signaling pathways will facilitate deconvolution of disease complexity as well as lead to development of novel therapies. In the present review, we focuses on the interplay between adipocytokines, gut microbiota, adrenomedullin, hyaluronan, vanin and matrix metalloproteinase affected by metabolic alteration and pancreatic tumor progression.
Conclusions: Metabolic diseases, such as obesity and T2DM, contribute PC development through altered metabolic pathways. Delineating key players in oncogenic development in pancreas due to metabolic disorder could be a beneficial strategy to combat cancers associated with metabolic diseases in particular, PC.
Databáze: MEDLINE
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