Forging C(sp 3 )-C(sp 3 ) Bonds with Carbon-Centered Radicals in the Synthesis of Complex Molecules.

Autor:	Pitre SP; Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States., Weires NA; Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States., Overman LE; Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Jazyk:	angličtina
Zdroj:	Journal of the American Chemical Society [J Am Chem Soc] 2019 Feb 20; Vol. 141 (7), pp. 2800-2813. Date of Electronic Publication: 2019 Jan 04.
DOI:	10.1021/jacs.8b11790
Abstrakt:	Radical fragment coupling reactions that unite intricate subunits have become an important class of transformations within the arena of complex molecule synthesis. This Perspective highlights some of the early contributions in this area, as well as more modern applications of radical fragment couplings in the preparation of natural products. Additionally, emphasis is placed on contemporary advances that allow for radical generation under mild conditions as a driving force for the implementation of radical fragment couplings in total synthesis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu