A Divergent Hepatitis D-Like Agent in Birds.

Autor: Wille M; WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. michelle.wille@influenzacentre.org., Netter HJ; Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Hans.Netter@mh.org.au., Littlejohn M; Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Margaret.Littlejohn@vidrl.org.au., Yuen L; Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Lilly.Yuen@vidrl.org.au., Shi M; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Mang.Shi@sydney.edu.au., Eden JS; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. js.eden@sydney.edu.au., Klaassen M; Centre for Integrative Ecology, Deakin University, Geelong, VIC 3220, Australia. Marcel.Klaassen@deakin.edu.au., Holmes EC; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Edward.Holmes@sydney.edu.au., Hurt AC; WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Aeron.Hurt@influenzacentre.org.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2018 Dec 17; Vol. 10 (12). Date of Electronic Publication: 2018 Dec 17.
DOI: 10.3390/v10120720
Abstrakt: Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje