Viral MHCI inhibition evades tissue-resident memory T cell formation and responses.

Autor: Lauron EJ; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Yang L; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Harvey IB; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Sojka DK; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Williams GD; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO., Paley MA; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Bern MD; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Park E; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Victorino F; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Boon ACM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO., Yokoyama WM; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO yokoyama@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Jazyk: angličtina
Zdroj: The Journal of experimental medicine [J Exp Med] 2019 Jan 07; Vol. 216 (1), pp. 117-132. Date of Electronic Publication: 2018 Dec 17.
DOI: 10.1084/jem.20181077
Abstrakt: Tissue-resident memory CD8 + T cells (T RM s) confer rapid protection and immunity against viral infections. Many viruses have evolved mechanisms to inhibit MHCI presentation in order to evade CD8 + T cells, suggesting that these mechanisms may also apply to T RM -mediated protection. However, the effects of viral MHCI inhibition on the function and generation of T RM s is unclear. Herein, we demonstrate that viral MHCI inhibition reduces the abundance of CD4 + and CD8 + T RM s, but its effects on the local microenvironment compensate to promote antigen-specific CD8 + T RM formation. Unexpectedly, local cognate antigen enhances CD8 + T RM development even in the context of viral MHCI inhibition and CD8 + T cell evasion, strongly suggesting a role for in situ cross-presentation in local antigen-driven T RM differentiation. However, local cognate antigen is not required for CD8 + T RM maintenance. We also show that viral MHCI inhibition efficiently evades CD8 + T RM effector functions. These findings indicate that viral evasion of MHCI antigen presentation has consequences on the development and response of antiviral T RM s.
(© 2018 Lauron et al.)
Databáze: MEDLINE
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