| Autor: |
Franklin JD; School of Health and Social Care, Teesside University, Middlesbrough, United Kingdom of Great Britain and Northern Ireland., Atkinson G; School of Health and Social Care, Teesside University, Middlesbrough, United Kingdom of Great Britain and Northern Ireland., Atkinson JM; Middlesbrough College, Middlesbrough, United Kingdom of Great Britain and Northern Ireland., Batterham AM; School of Health and Social Care, Teesside University, Middlesbrough, United Kingdom of Great Britain and Northern Ireland. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of sports medicine [Int J Sports Med] 2019 Feb; Vol. 40 (2), pp. 77-87. Date of Electronic Publication: 2018 Dec 17. |
| DOI: |
10.1055/a-0802-9175 |
| Abstrakt: |
To evaluate the magnitude of the difference in VO 2peak between patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) and apparently healthy controls, 7 databases (Cochrane, PubMed, PsycINFO, Web of Knowledge, Embase, Scopus, Medline) were searched for articles published up to March 2018. Search terms included "chronic fatigue syndrom*"AND ("peak" OR "maxim*" OR "max") AND ("oxygen uptake" OR "oxygen consumption" OR "VO2peak" or "VO2max". Eligibility criteria were adults>18 y with clinically diagnosed CFS/ME, with VO 2peak measured in a maximal test and compared against an apparently healthy control group. The methodological quality of included studies was assessed using a modified Systematic Appraisal of Quality for Observational Research critical appraisal framework. A random effects meta-analysis was conducted on 32 cross-sectional studies (effects). Pooled mean VO 2peak was 5.2 (95% CI: 3.8-6.6) ml.kg -1 min -1 lower in CFS/ME patients vs. healthy controls. Between-study variability (Tau) was 3.4 (1.5-4.5) ml.kg -1 min -1 indicating substantial heterogeneity. The 95% prediction interval was -1.9 to 12.2 ml.kg -1 min -1 . The probability that the effect in a future study would be>the minimum clinically important difference of 1.1 ml.kg -1 min -1 (in favour of controls) was 0.88 - likely to be clinically relevant. Synthesis of the available evidence indicates that CFS/ME patients have a substantially reduced VO 2peak compared to controls.
Competing Interests: The authors declare no conflict of interest.
(© Georg Thieme Verlag KG Stuttgart · New York.) |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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