NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease.

Autor: Gastaldi M; Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy., Arbasino C; Neurology Unit, ASST Pavia-Ospedale Civile di Voghera, Voghera, Italy., Dallocchio C; Neurology Unit, ASST Pavia-Ospedale Civile di Voghera, Voghera, Italy., Diamanti L; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy., Bini P; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy., Marchioni E; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy., Franciotta D; Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy. Electronic address: diego.franciotta@mondino.it.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2019 Mar 15; Vol. 328, pp. 35-37. Date of Electronic Publication: 2018 Dec 12.
DOI: 10.1016/j.jneuroim.2018.12.002
Abstrakt: We describe the case of a woman with Parkinson disease who developed an N-methyl-d-aspartate receptor antibody-mediated encephalitis. As a novelty, the encephalitis presentation mimicked a worsening of the pre-existing extrapyramidal syndrome, manifesting mainly as severe bradykinesia and, eventually, akinesia. Brain MRI was normal, whereas cerebrospinal fluid (CSF) analysis disclosed unique-to-CSF oligoclonal bands. Prompt identification and timely immunotherapy led to a complete recovery.
(Copyright © 2018. Published by Elsevier B.V.)
Databáze: MEDLINE
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