Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats.

Autor: Koriem KMM; Department of Medical Physiology, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: kkoriem@yahoo.com., Arbid MS; Department of Pharmacology, National Research Centre, Dokki, Cairo 12622, Egypt., Saleh HN; Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Jazyk: angličtina
Zdroj: Journal of integrative medicine [J Integr Med] 2019 Jan; Vol. 17 (1), pp. 57-65. Date of Electronic Publication: 2018 Dec 05.
DOI: 10.1016/j.joim.2018.12.001
Abstrakt: Objective: Psidium guajava occurs worldwide in tropical and subtropical areas. It has been used to treat inflammation, diabetes, fever, hypertension and ulcers. However, its antidiarrheal and protein conservative activities still need to be investigated.
Methods: Fifty-four male rats were divided into normal and diarrheal rats. The normal rats were divided into 4 groups: control, low-dose P. guajava leaf extract (50 mg/kg), high-dose P. guajava leaf extract (100 mg/kg) and gallic acid. Treatments were administrated orally in 1 mL saline for a 1-month period. The diarrheal rats were divided into 5 groups: desmopressin (0.2 mg/kg) drug, low-dose P. guajava leaf extract (50 mg/kg), high-dose P. guajava leaf extract (100 mg/kg), gallic acid and an untreated control. Doses were given daily for a 1-month period while the untreated control received no treatment.
Results: Diarrhea was responsible for an observed decline in kidney weight and serum sodium, potassium and chloride. Further, diarrhea was positively correlated with a significant increase in urine volume, and excretion of electrolytes, serum urea, creatinine and uric acid in the urine. In contrast, there was a proportional increase in the lipid peroxidation value in diarrhea and a significant decline was observed in serum superoxide dismutase, glutathione peroxidase and glutathione levels in diarrhea. Also, diarrhea inhibited blood proteins. The oral intake of P. guajava leaf extract by diarrheal rats restored all of these parameters to near normal levels. High-dose P. guajava leaf extract was more effective than the same compound at a low dose.
Conclusion: P. guajava leaf extract elicited antidiarrheal and protein conservative effects.
(Copyright © 2018 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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