Hidden hearing loss in children and adolescents with sickle cell anemia.

Autor: Rissatto-Lago MR; Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil; Department of Life Science, State University of Bahia, Salvador, Bahia, Brazil. Electronic address: mararenata@uol.com.br., da Cruz Fernandes L; Department of Speech Therapy, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, Brazil., Lyra IM; University Hospital Professor Edgar Santos of Federal University of Bahia, Salvador, Bahia, Brazil., Terse-Ramos R; Department of Pediatrics, School of Medicine of Bahia, Federal University of Bahia, Salvador, Bahia, Brazil., Teixeira R; Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil; Department of Pediatrics, School of Medicine of Bahia, Federal University of Bahia, Salvador, Bahia, Brazil., Salles C; Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil; University Hospital Professor Edgar Santos of Federal University of Bahia, Salvador, Bahia, Brazil., Teixeira Ladeia AM; Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil.
Jazyk: angličtina
Zdroj: International journal of pediatric otorhinolaryngology [Int J Pediatr Otorhinolaryngol] 2019 Jan; Vol. 116, pp. 186-191. Date of Electronic Publication: 2018 Nov 02.
DOI: 10.1016/j.ijporl.2018.10.042
Abstrakt: Objective: To evaluate the auditory system for hidden hearing loss (HHL) and its association with clinical variables and endothelial dysfunction (ED) in children and adolescents with sickle cell anemia (SCA).
Methods: Participants included 37 patients with stable SCA and 44 healthy controls (HC group) (aged 6-18 years) with hearing thresholds ≤ 20 dB (dB) were evaluated for pure tone audiometry, tympanometry, acoustic reflex, otoacoustic emission, and auditory evoked potentials. Laboratory analysis of the lipid profile, and C-reactive protein levels and endothelial function using ultrasonographic imaging of the brachial artery to assess flow-mediated dilation were performed.
Results: The SCA group presented with a higher rate of increased contralateral acoustic reflex thresholds, compared to those in the HC group at all frequencies and in both ears (p < 0.05). There were significant differences in the brainstem auditory evoked potentials between the SCA and HC groups. In the SCA group, the waves III and V latencies were increased (p = 0.006 and 0.004 respectively), and the I-III and I-V interpeak intervals were longer (p = 0.015 and 0.018 respectively) than those in the HC group. There was no association between the audiological measures and clinical and metabolic variables and sickle cell anemia complications including endothelial function and therapy.
Conclusion: In conclusion, our findings suggest that damage in the auditory system in SCA patients can be present involving retrocochlear structures, causing functional deficits without deterioration of auditory sensitivity.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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