Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application.

Autor: Morais ES; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Silva NHCS; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Sintra TE; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Santos SAO; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Neves BM; Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal., Almeida IF; UCIBIO-REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4051-401 Porto, Portugal., Costa PC; UCIBIO-REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4051-401 Porto, Portugal., Correia-Sá I; Department of Plastic, Aesthetic, Reconstructive and Aesthetic Surgery, Centro Hospitalar de S. João, 4200-319 Porto, Portugal., Ventura SPM; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Silvestre AJD; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Freire MG; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Freire CSR; CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: cfreire@ua.pt.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2019 Feb 15; Vol. 206, pp. 187-197. Date of Electronic Publication: 2018 Oct 25.
DOI: 10.1016/j.carbpol.2018.10.051
Abstrakt: The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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