[The mechanism of stimforte action on herpesvirus infection.]

Autor:	Maldov DG; SKY LTD, Moscow, 129301, Russian Federation., Andronova VL; National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russian Federation., Grigorian SS; National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russian Federation., Isaeva EI; National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russian Federation., Balakina AA; Institute of Problems of Chemical Physics, 142432, Moscow Region, Russian Federation., Terentyev AA; Institute of Problems of Chemical Physics, 142432, Moscow Region, Russian Federation., Ilyichev AV; SKY LTD, Moscow, 129301, Russian Federation., Galegov GA; National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russian Federation.
Jazyk:	ruština
Zdroj:	Voprosy virusologii [Vopr Virusol] 2018; Vol. 63 (5), pp. 218-223.
DOI:	10.18821/0507-4088-2018-63-5-218-223
Abstrakt:	Increased protease activity and a significant amount of granzyme B were observed in in organs of mice infected with acute herpes simplex virus HSV-1 with the introduction of Stimforte (100 or 250 µg/mouse). Thus, this drug activates killer cells, which play an extremely important role in the suppression of HSV-1 infection. Although the administration of Stimforte (100 μg/mouse) to intact mice results in the activation of IFN-β production and does not activate the production of IFN-λ, Stimforte administration to animals infected with HSV-1 reduces production of IFN-β in serum, brain and lungs, whereas the production of IFN-λ considerably increases as the result of administration of 100 μg/mouse of Stimforte. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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