[The comparison of two chemiluminescent models for assessing anti-oxidative activity of blood serum of patients with liver pathology].

Autor: Sazhina NN; The Federal state budget institution of science 'The N.M. Emanuel institute of biochemical physics' of the Russian academy of sciences, 119334, Moscow, Russia., Popov IN; The research institute of anti-oxidation therapy, Berlin, Germany., Titov VN; The Federal state budget scientifc institution 'the Russian cardiologic R&D production complex' of Minzdrav of Russia, 121552, Moscow, Russia.
Jazyk: ruština
Zdroj: Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (1), pp. 16-21.
DOI: 10.18821/0869-2084-2018-63-1-16-21
Abstrakt: The comparative assessment was carried out concerning anti-oxidation activity of blood serum of patients with liver pathology using two chemiluminescent techniques with different models of free radical oxidation: «Hb-Н2О2-luminol» и «ABAP-luminol». The reliable but low correlation of results was established (r=0,798) related mainly to difference in mechanisms of initiation of free radicals and effect of blood serum on initiation process. This effect is stronger manifested in model «Hb-Н2О2-luminol». The discrepancy of results of measurement is more expressed in patients with anomalous higher content of bilirubin in blood. Thereupon, oxidation model «ABAP-luminol» is to be considered as a more preferable for clinical practice.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE