Suprathreshold laser injuries in excised porcine skin for millisecond exposures at 1070 nm.
| Autor: | DeLisi MP; Engility Corp., JBSA Fort Sam Houston, Texas, United States., Peterson AM; Engility Corp., JBSA Fort Sam Houston, Texas, United States., Lile LA; 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bio, United States., Noojin GD; Engility Corp., JBSA Fort Sam Houston, Texas, United States., Shingledecker AD; Engility Corp., JBSA Fort Sam Houston, Texas, United States., Stolarski DJ; Engility Corp., JBSA Fort Sam Houston, Texas, United States., Oian CA; 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bio, United States., Kumru SS; 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bio, United States., Thomas RJ; 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bio, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of biomedical optics [J Biomed Opt] 2018 Dec; Vol. 23 (12), pp. 1-11. |
| DOI: | 10.1117/1.JBO.23.12.125001 |
| Abstrakt: | Skin injury response to near-infrared (NIR) laser radiation between the minimum visible lesion threshold and ablation onset is not well understood. This study utilizes a 1070-nm diode-pumped Yb-fiber laser to explore the response of excised porcine skin to high-energy exposures in the suprathreshold injury region without inducing ablation. Concurrent high-speed videography is employed to determine a dichotomous response for three progressive damage categories: observable surface distortion, surface bubble formation due to contained intracutaneous water vaporization, and surface bubble rupture during exposure. Median effective dose (ED50) values are calculated in these categories for 3- and 100-ms pulses with beam diameters (1 / e2) of 3 mm (28, 35, and 49 J / cm2) and 7 mm (96, 141, and 212 J / cm2), respectively. Double-pulse cases are secondarily investigated. Experimental data are compared with the maximum permissible exposure limits and ablation onset simulated by a one-dimensional multiphysics model. Logistic regression analysis predicted injury events with ∼90 % of accuracy. The distinction of skin response into progressive damage categories expands the current understanding of high-energy laser safety while underlining the unique biophysical effects during induced water phase change in tissue. These results prove to be useful in the diagnosis and treatment of NIR laser injuries. ((2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).) |
| Databáze: | MEDLINE |
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