Antimicrobial activity of ceftolozane-tazobactam against multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa clinical isolates from a Spanish hospital.
| Autor: | López-Calleja AI; Ana Isabel López-Calleja, Servicio de Microbiología, Hospital Universitario Miguel Servet. IIS Aragón. 3ª planta Edificio de Consultas Externas - c/ Padre Arrupe s/n, 50009 Zaragoza, Spain. ailopezc@aragon.es., Morilla Morales E, Nuñez Medina R, Fernández Esgueva M, Sahagún Pareja J, García-Lechuz Moya JM, Ferrer Cerón I, Viñuelas Bayon J, Rezusta López A |
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| Jazyk: | angličtina |
| Zdroj: | Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia [Rev Esp Quimioter] 2019 Feb; Vol. 32 (1), pp. 68-72. Date of Electronic Publication: 2018 Dec 14. |
| Abstrakt: | Objective: Our objective was to evaluate the in vitro activity of ceftolozane-tazobactam against multidrug resistant (MDR) and extensively drug-resistant (XDR) non metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates at Hospital Universitario Miguel Servet (Zaragoza, Spain) from February 2016 to October 2017. Methods: We evaluated the in vitro activity of ceftolozane-tazobactam and other antipseudomonal antibiotics against 12 MDR and 117 XDR non metallo-β-lactamase producing P. aeruginosa isolates. Ceftolozane-tazobactam minimal inhibitory concentrations (MICs) were determined by MIC gradient diffusion test strip. Results: Among the 129 MDR/XDR isolates included, 119 (92.2%) were susceptible to ceftolozane-tazobactam, and ten (7.8%) were resistant. MIC50 was 2 mg/L, and MIC90 4 mg/L. Ceftolozane-tazobactam was the second most active antibiotic after colistin, overtaking amikacin. Conclusions: Ceftolozane-tazobactam is a valuable treatment option for MDR and XDR P. aeruginosa infections in our setting. (©The Author 2019. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).) |
| Databáze: | MEDLINE |
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