Frequency of Osteoporosis and Vertebral Fractures in Chronic Obstructive Pulmonary Disease (COPD) Patients.

Autor:	Gazzotti MR; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Roco CM; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Pradella CO; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Nascimento OA; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Porto EF; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Adas M; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Lazaretti-Castro M; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil., Jardim JR; Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil. Electronic address: jardimpneumo@gmail.com.
Jazyk:	English; Spanish; Castilian
Zdroj:	Archivos de bronconeumologia [Arch Bronconeumol (Engl Ed)] 2019 May; Vol. 55 (5), pp. 252-257. Date of Electronic Publication: 2018 Dec 09.
DOI:	10.1016/j.arbres.2018.10.010
Abstrakt:	Background: Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or microarchitectural deterioration of bone. Osteoporosis is a risk factor for fractures specially in patients with advanced COPD. The aim of this cross-sectional study was to determine the frequency of osteoporosis and vertebral fracture in COPD patients. Methods: We evaluated 91 COPD patients and compared to 82 healthy subjects (control group) matched for gender and age. We measured the bone mineral density by means of dual energy X-ray absorptiometry (DXA), evaluating the lumbar vertebra (L1-L4), proximal femur and total femur and evaluated vertebral fractures in thoracic and lumbar spine using X-ray. We questioned patients whether they had had any fall that resulted in any fracture in the past five years. Results: Males comprised 60.4% of COPD group and 57.3% of the control group. Mean age was 66.2±9.2 years for COPD group and 64.2±8.8 for the control group. The frequency of osteoporosis in the COPD group was 29.7% and 18.3% in control group (p=0.007). The frequency of vertebral fractures was 18.6% in the COPD group and 9.0% in control group (p=0.06). The frequency of reported falls at resulting in any fracture was 36.3% in the COPD group and 7.3% in control group (p=0.001). Conclusions: Our data indicate that COPD patients present a high frequency of osteoporosis and falls seem to be an important factor for vertebral fracture. (Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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