Dose-Dependent Effects of Closed-Loop tACS Delivered During Slow-Wave Oscillations on Memory Consolidation.

Autor:	Jones AP; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Choe J; Center for Human-Machine Collaboration, Information and Systems Sciences Laboratory, HRL Laboratories, LLC, Malibu, CA, United States., Bryant NB; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Robinson CSH; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States.; The Mind Research Network, Albuquerque, NM, United States., Ketz NA; Center for Human-Machine Collaboration, Information and Systems Sciences Laboratory, HRL Laboratories, LLC, Malibu, CA, United States., Skorheim SW; Center for Human-Machine Collaboration, Information and Systems Sciences Laboratory, HRL Laboratories, LLC, Malibu, CA, United States., Combs A; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Lamphere ML; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Robert B; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Gill HA; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Heinrich MD; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States., Howard MD; Center for Human-Machine Collaboration, Information and Systems Sciences Laboratory, HRL Laboratories, LLC, Malibu, CA, United States., Clark VP; Psychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, United States.; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States.; The Mind Research Network, Albuquerque, NM, United States.; Department of Neuroscience, University of New Mexico School of Medicine, Albuquerque, NM, United States., Pilly PK; Center for Human-Machine Collaboration, Information and Systems Sciences Laboratory, HRL Laboratories, LLC, Malibu, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2018 Nov 27; Vol. 12, pp. 867. Date of Electronic Publication: 2018 Nov 27 (Print Publication: 2018).
DOI:	10.3389/fnins.2018.00867
Abstrakt:	Sleep is critically important to consolidate information learned throughout the day. Slow-wave sleep (SWS) serves to consolidate declarative memories, a process previously modulated with open-loop non-invasive electrical stimulation, though not always effectively. These failures to replicate could be explained by the fact that stimulation has only been performed in open-loop, as opposed to closed-loop where phase and frequency of the endogenous slow-wave oscillations (SWOs) are matched for optimal timing. The current study investigated the effects of closed-loop transcranial Alternating Current Stimulation (tACS) targeting SWOs during sleep on memory consolidation. 21 participants took part in a three-night, counterbalanced, randomized, single-blind, within-subjects study, investigating performance changes (correct rate and F1 score) on images in a target detection task over 24 h. During sleep, 1.5 mA closed-loop tACS was delivered in phase over electrodes at F3 and F4 and 180° out of phase over electrodes at bilateral mastoids at the frequency (range 0.5-1.2 Hz) and phase of ongoing SWOs for a duration of 5 cycles in each discrete event throughout the night. Data were analyzed in a repeated measures ANOVA framework, and results show that verum stimulation improved post-sleep performance specifically on generalized versions of images used in training at both morning and afternoon tests compared to sham, suggesting the facilitation of schematization of information, but not of rote, veridical recall. We also found a surprising inverted U-shaped dose effect of sleep tACS, which is interpreted in terms of tACS-induced faciliatory and subsequent refractory dynamics of SWO power in scalp EEG. This is the first study showing a selective modulation of long-term memory generalization using a novel closed-loop tACS approach, which holds great potential for both healthy and neuropsychiatric populations.
Databáze:	MEDLINE
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